How is Ketamine different than other Dissociatives?

[LSD-Rumi]

How does it compare to PCE, PCP, DCK, etc..?

Edited October 13, 2023 by LSD-Rumi

[Schizophonia]

Apparently, it's a pretty strict NMDA receptor antagonist.
PCP, PCE etc. have stronger third-party effects, such as agonism of opioid receptors.
DXM is a Sigma receptor agonist, and is more psychedelic.
Etc.

The effect also depends a lot on the isomer, esketamine has a different pharmacology from erketamine.

[Oppositionless]

The reason they started using ketamine instead of pcp as a surgical anaesthetic is because pcp can cause psychosis, ketamine not so. Or at the very least, it is many times less likely to.

Edited October 13, 2023 by Oppositionless