5 meo dmt to lsd dose equivalent

[Johnnyyeah]

Was wondering if anyone (perhaps leo)could tell me the dose conversion on these 2 substances blank ug oh lsd equals blank mg of 5 neo just curious. When I was 18 I did a real  1500 ug of lsd, not a I say it's this much but it's really something nowhere close but a real 1500 micrograms 10 150 mic hits and ended up in the hospital completely insane. The average hit of blotter nowadays despite outlandish claims is 50 mics despite what ppl say. Just wondering what the real dose conversion of 5 neo yo lsd is

Edited March 9, 2021 by Johnnyyeah

[Leo Gura]

There is no comparison. They a very different substances.

[Carl-Richard]

Quote

5-MeO-DMT binds to the 5-HT1A receptor subtype with much higher affinity (Ki, < 10 nM) than 5-HT2 receptor (>1000 nM).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028383/

 

Quote

In humans, recreational doses of LSD can affect 5-HT1A (Ki=1.1nM), 5-HT2A (Ki=2.9nM), (...).

https://en.wikipedia.org/wiki/Lysergic_acid_diethylamide#Pharmacology

 

For 5-MeO-DMT, the low affinity for 2A is thought to explain the lack of characteristic psychedelic visuals, and the high affinity for 1A is thought to explain the strong ego surpression effects (ego death). It's much more complicated than that, but you can atleast start to understand the differences by looking at the receptor subunits. In other words, 5-MeO-DMT is not very translatable to other serotonergic psychedelics like LSD or Psilocybin.

Edited March 9, 2021 by Carl-Richard

[Dazgwny]

This sort of thing has crossed my mind before too. But my intuition has told me that it’s clearly something where comparisons can’t be made, other than they are both expanding your consciousness and a state altering. But reading what’s said about 5meo they must generate totally different experiences. I wonder sometimes just what the hell must a proper 5meo trip entail. Because I’ve had some massively deep awakenings from the use of lsd, to the point where you think you’ve completely got it, only to find the next time you go even deeper and realise you were nowhere near, and in all likelihood nowhere near the depths of where this all goes again, even though you feel you’ve gone as deep as need be to have gotten it all. And it turns out ya just havnt, nowhere near. Like there’s no end, which I suppose does make sense. I feel like I’m getting towards my limits with lsd, if not already hit them before it becomes too dangerous, from a physical standpoint. I know I can still have deeper awakenings with it, and to different aspects, but it seems that 5meo is a different beast altogether from what I can tell, and currently I don’t have access. So intrigued as to what it entails, at varying degrees of dosage. Leo says he has lesser dosages, others say they just blast out with larger ones. It’s difficult to comprehend what they experience. But my guess is that no dosage of lsd is going to be comparable to 5meo