Questions on mushrooms

[karkaore]

Are there any factors in ones diet that would make mushrooms ineffective? Are there any psychological factors that would make them ineffective? Maybe antidepressants could cause mushroom inefficiency? I am trying to find out why for example one time i take 1g of mushrooms I am tripping so hard I can't find my tent in the camping and the other time I take 1g of the same mushrooms I get minimal to zero effect.?? Keep in mind that I am aware of the tolerance and i do at least 2 weeks break between the trips.

I have a friend who takes antidepressants so I've decided to give her some mushrooms. She took 1.5g and felt nothing. This is unfortunate. Some months prior to this she had a truffle trip which she said was a powerful trip. (She wasn't on antidepressants then)

Any thoughts on this? Anyone had similar experiences with mushrooms (one time very potent, other time - nothing at all)? Maybe there is something I am missing here? What's your routine couple of days prior to taking mushrooms?

Thank you!

[Fran11]

1 hour ago, karkaore said:

I have a friend who takes antidepressants so I've decided to give her some mushrooms. She took 1.5g and felt nothing. This is unfortunate. Some months prior to this she had a truffle trip which she said was a powerful trip. (She wasn't on antidepressants then)

 

What antidepressents exactly? Some may compete with the psychedelic for the neuronal receptors and/or cause down-regulation (disminishing number) of these receptors.

[karkaore]

16 minutes ago, Fran11 said:

What antidepressents exactly? Some may compete with the psychedelic for the neuronal receptors and/or cause down-regulation (disminishing number) of these receptors.

I see. This would make sense.

Here is a list of medicines she takes: Leponex 0.1 and 0.025, Cyclodol 0.002, Depakine chrono 0.5, Quetiapin 0.025, Coaxil 12.5mg

[Fran11]

20 hours ago, karkaore said:

I see. This would make sense.

Here is a list of medicines she takes: Leponex 0.1 and 0.025, Cyclodol 0.002, Depakine chrono 0.5, Quetiapin 0.025, Coaxil 12.5mg

Clozapine (Leponex) and Quetiapina do bind to 5HT (among others) receptors like mushrooms. There might be other more complex interactions that I'm missing beyond the direct effcts on the receptors, pharmacological interactions are complex and even more so regarding the brain, only a specialist would know in detail really.

I can't give you medical advise regarding suspending/lowering their use of course. 

In my humble opinions a higher dose of mushrooms should do it

Do take into account that it might temporarely alter the functioning of the antidepressents until her brain re-adepts after the trip, because it works on the opposite way as well, so again, you may wanna talk to an open minded professional.

Edited August 14, 2020 by Fran11

[karkaore]

@Fran11 Thank you very much for the info! ?

[karkaore]

Me myself have never taken any antidepressants ever. Any ideas why would the same dosage of the same shrooms would sometimes provide a powerful trip and sometimes would have little to no effect?

I am getting more and more disappointed about shrooms as out of 5 times I took them, 3 times felt no effects at all.

[DrewNows]

@karkaore eat clean, hydrate and plan out a good trip in a healthy environment. I try not to consume anything 4-6 hours prior. Set yourself up for success, it's not some magic pill, it's a tool for deep meditative states. It can be abused just like anything else, so using with clear intentions is wise 

[Nahm]

On 8/13/2020 at 10:15 AM, karkaore said:

one time i take 1g of mushrooms I am tripping so hard I can't find my tent in the camping and the other time I take 1g of the same mushrooms I get minimal to zero effect.??

Sorry if it was already asked and I missed it...were both trips from the same batch? The potency might be very different, one batch to the next. If it was two different batches, was the batch you felt no effects from the same batch she felt no effects from? Also, to make it more complicated, someone could feel effects from a batch that someone else does not. 

Side note, also experienced tripping / can’t find my tent. Hilarious. Good times. 

On your friend’s behalf...

On 8/13/2020 at 10:15 AM, karkaore said:

Some months prior to this she had a truffle trip which she said was a powerful trip. (She wasn't on antidepressants then)

That imo tends to explain it. Perhaps the powerful trip she did have brought up some stuff which was not worked through, and that has something to do with going from no meds, to what is imo a lot of meds. That could have been done, and working, in the direction of relief toward more well being. It also could have been done in avoidance of feeling, and suppression. 

Also, it is not the same for everyone. Someone else could be on the exact same meds and dosages, and have profound experiences on mushrooms. For her, apparently the prescriptions nullified or blocked the effects of the mushrooms.

Coming from that reality is literally love, and she is literally love, the list you shared strikes me as on the heavy side of suppression of misunderstanding of feeling & thoughts. In a way, mushrooms are the opposite direction, the complete diving into the actuality of feeling & thoughts, ultimately finding the only ‘substance’ of them, is love. Some carry little, and got straight to heaven’, some carry much beliefs about themself, and go through ‘hell’. It’s possible that all of those meds add up to a suppression which the mushrooms are not putting a dent in. The catch 22, is considering taking a higher dose of mushrooms to ‘push through’ that suppression can be a risky thing to do. Especially if the reason the meds were started in the first place was essentially suppression.

What makes it more complicated, is those meds are for psychosis, schizophrenia, pain relief, mania / bipolarity, seizures, and major depressive disorder. Those are ‘things’ sometimes experienced on trips, in the sense of the entire path, or, what all the trips add up to. Again, that depends on what one is holding onto, and thus stands to let go of. Mushrooms are not the gentle slow & steady way to let go. Maybe micro dosing, or .5g, 1g trips over months could be. These ‘stages’ that she is taking meds for are experienced upon transcending the finite mind, and in that respect could be thought of as the ‘outer edges’ of the finite mind, sort of the ‘falling apart’ experientially, but being transcended in the actuality being inevitably realized to be infinity, Love, appearing as the finite mind. So in hindsight, what seemed like a ‘falling apart’, was actually in route to total transcendence.  

Also, some of the meds are outside of what would typically be prescribed, which is worth understanding why for her I would think. Might just be geographical reasons, or simply what the dr prescribed without a reason, or what was available, or what was covered by her insurance plan. 

I would read this, and suggest she does too...

https://www.synthesisretreat.com/psilocybin-and-ssri-snri-interactions

In any case, the biggest picture, and the actuality of her and of her experience, is the love that she truly is. So that brings to mind...aside from all these meds, and taking mushrooms...where’s she at with self-love, appreciation, gratitude, stopping and smelling the roses so to speak, expressing how she is feeling, putting any emotional pain into creating beauty, etc?

 

 

[karkaore]

20 minutes ago, Nahm said:

were both trips from the same batch?

Batches indeed were not the same. Was thinking about this too. Potency regarding shrooms is a bummer.

24 minutes ago, Nahm said:

was the batch you felt no effects from the same batch she felt no effects from?

Yes. For me they were very potent, same as the other friend who took them with me. But for her there were no effects. She doesn't have a very clean diet too (this is where the question about diet came from). I do have a clean diet especially couple of days prior to trips, do not consume any food either before taking the substance. But wouldn't it make sense that even if the diet is bad, the substance would have to take effect sooner or later anyway?

32 minutes ago, Nahm said:

Coming from that reality is literally love, and she is literally love, the list you shared strikes me as on the heavy side of suppression of misunderstanding of feeling & thoughts.

That was my reaction when she provided me with the list of medicines she takes. She told me that the trip she had isn't the reason for her "need" to take the meds. However, the reason she provided me with somehow does not sell for me. Maybe I'm just too ignorant.

37 minutes ago, Nahm said:

where’s she at with self-love, appreciation, gratitude, stopping and smelling the roses so to speak, expressing how she is feeling, putting any emotional pain into creating beauty, etc?

She is very, very closed up. Fragile. Her actions tells me that she doesn't trust her self. From where I am now, it's very hard, nearly impossible to shine at least a bit of light onto her emotional pain and help her understand her self. I don't have the understanding nor the maturity needed on my own emotional being to cope with the ignorance that she is in. "My doctor told me, so I must" is what she sands by. Either she is scared to shit to try and look in there for herself or she doesn't see the need for it and thinks that society will solve her life.

And the fucking meds are making her numb as hell. She got very, very lazy too. Gaining weight, eating every two hours. Doesn't care what she eats, doesn't care about any exercise either. It hurts so bad watching her go through this.

[Nahm]

37 minutes ago, karkaore said:

But wouldn't it make sense that even if the diet is bad, the substance would have to take effect sooner or later anyway?

Think of drinking three beers after a big meal, vs an empty stomach. 

Geez, she is a rough place. Hopefully she reaches a turning point soon. Sorry to hear that.