Ranking of the best psychedelics for consciousness work

[Enlightenment]

I know some people are going to say that those drugs listed are very different than 5-MeO-DMT, and it's true, there seem to be nothing like 5-MeO-DMT receptor and experience wise, but I think its valuable to know which ones are closest anyway.

Based on Thomas Ray's research, what it takes to have a high chance for ego death/experiencing absolute infinity is a strong activation of serotonin-7 and low activation of serotonin-2 at the same time, because serotonin-2 loads "mental organs" into consciousness and because of that self tends to not dissolve.

1)  5-MeO-DMT (obviously) 
     It has a very high affinity for 5-HT7 and lowest (imperceptible) affinity for 5-HT2

2)  LSD
    It has a very high affinity for 5-HT7 and also for 5-HT2, however it only activates serotonin-2 0-25% that of almost all other psychedelics, also          I've found at least 4 very high dose trip raports that sounded exactly like a 5-MeO-DMT breakthrough. The problem is that very high doses can      last something crazy like 20h

3/4)  Psilocin (Magic Mushrooms)
      Moderately high affinity for 5-HT7, high affinity for 5-HT2, but only 24-51% activation of 5-HT2

3/4)  5-MeO-MIPT
      Very high affinity for 5-HT7, and moderately high affinity for 5-HT2. Martin Ball considers it to be the second best tool for non-duality work,            but some people claim that it's not that good, I don't know.

5)    DPT, 2C-E, 5-MeO-DIPT, DMT(?)

 

 You can read more about it here

 

 

Edited September 10, 2018 by Enlightenment

[Enlightenment]

@Outer Well, I'm rather referring to how good certain psychedelic is for experiencing a temporary ultimate state that is completely dysfunctional and not like persistent non-dual awareness in daily life (what Eckhart Tolle is talking about). More like a blast to your mind to enable you to see your subconscious aversion, ill will, fears etc.

[Forestluv]

The type of psychedelic is just one factor. Mindset, setting and dosage are also important factors. As well, each can reveal different aspects of truth. It's weird to say one aspect of truth is "better".

In terms of depth of insight, I would roughly rank them as: (number of trips in parenthesis)

1. 5-meo-dmt (about 10)

2. Ayahuasca ceremonies (3)

3. 4-Aco-dmt (about 30)

4. San Pedro (2)

5. LSD (about 20)

6. A handful of other research chemicals like ALD-52, ETH-LAD, 4-HO-Met etc (about 10)

What put Aya so high, wasn't just the drug effects. The environment of the ceremony added greatly.

[PsiloPutty]

@Serotoninluv  Have you never done mushrooms, or did they just not make your insight list?

 

[Forestluv]

59 minutes ago, PsiloPutty said:

@Serotoninluv  Have you never done mushrooms, or did they just not make your insight list?

 

I did shrooms decades ago when I was a young lad. I know growing shrooms is easy, yet I suck at growing anything and I would probably screw it up.

I did a lot of reading on 4-Aco-dmt and IMO it's close enough to shrooms that I put them in the same category (I know others will disagree. . . ). It's much easier for me to get high quality 4-Aco-dmt than grow shrooms.

[PsiloPutty]

@Serotoninluv  Right, fair enough.  

 

[Leo Gura]

2C-B is surprisingly powerful and profound for me.

Although my faves so far are 5-MeO and LSD.

[Schizophonia]

LSD is too alien and "dirty" to work on, anything too dopaminergic (LSD, other lysergamides, Weed, MDMA) will get me too high. There are also more pronounced side effects (tight jaw, feeling of having peed yourself, sometimes feeling of having sniffed steel due to vasoconstriction...

5-MeO-DMT is disgusting, not only is there a strong body load (especially nausea) but it is absolutely anxiety-provoking in high doses. It is good only for experiencing infinity.

5-MeO-MIPT looks somehow a bit like LSD, but more cold and brutal.

4 HO MET is almost perfect. 

[Jannes]

These substances can evolve a lot. Psylocibin was light, fun, unclear and dirty at the beginning and after just tipping my foot in 5meo dmt and a bit of lsd it has gotten super deep and clear. 

[emil1234]

havent done 5meo yet, but so far: 

1. DMT

2. ayahuasca

3. lsd

[Yimpa]

1 hour ago, Schizophonia said:

feeling of having peed yourself

Haha, yeah I suffer with this one occasionally 

[Schizophonia]

1 hour ago, Yimpa said:

Haha, yeah I suffer with this one occasionally 

Talking about pee, i forgot constipation and the fact of not knowing if I’m actually burning myself in the shower

[Chadders]

Interesting that LSD is better for consciousness work based on the receptors than mushrooms. thought they were much the same

I have been wondering about continuing with mushrooms or going back to LSD. This is making me think the latter now 

[What Am I]

22 minutes ago, Chadders said:

Interesting that LSD is better for consciousness work based on the receptors than mushrooms. thought they were much the same

I have been wondering about continuing with mushrooms or going back to LSD. This is making me think the latter now 

LSD has a higher likelihood of producing unified states of consciousness via energetic release. That's not to say it's overall better though. There's plenty of drawbacks in comparison to mushrooms.

[Jannes]

21 minutes ago, Chadders said:

Interesting that LSD is better for consciousness work based on the receptors than mushrooms. thought they were much the same

I have been wondering about continuing with mushrooms or going back to LSD. This is making me think the latter now 

It's different for everyone you should try both and see which effect it has on you. And in my experience they influence each other a lot. After lsd my psylocibin trips get more lsd like. 

[ricachica]

Very interesting, I will be researching 5HT7 more now.

What are your thoughts on which ones will pair best with each mental health disorder in psychedelic-assisted therapy?

[Chadders]

@Jannes yeh have done both. Tbh I preferred the LSD just felt amazing on the highs though did have a very challenging experience once. Most of the insights have come from my more challenging trips. 

I haven’t tried DmT. This is something I want to explore 

[Yimpa]

15 hours ago, ricachica said:

What are your thoughts on which ones will pair best with each mental health disorder in psychedelic-assisted therapy?

We’ve only started researching this area, so it is difficult to say. 

[James123]

On 9/10/2018 at 4:51 PM, Enlightenment said:

I know some people are going to say that those drugs listed are very different than 5-MeO-DMT, and it's true, there seem to be nothing like 5-MeO-DMT receptor and experience wise, but I think its valuable to know which ones are closest anyway.

Based on Thomas Ray's research, what it takes to have a high chance for ego death/experiencing absolute infinity is a strong activation of serotonin-7 and low activation of serotonin-2 at the same time, because serotonin-2 loads "mental organs" into consciousness and because of that self tends to not dissolve.

1)  5-MeO-DMT (obviously) 
     It has a very high affinity for 5-HT7 and lowest (imperceptible) affinity for 5-HT2

2)  LSD
    It has a very high affinity for 5-HT7 and also for 5-HT2, however it only activates serotonin-2 0-25% that of almost all other psychedelics, also          I've found at least 4 very high dose trip raports that sounded exactly like a 5-MeO-DMT breakthrough. The problem is that very high doses can      last something crazy like 20h

3/4)  Psilocin (Magic Mushrooms)
      Moderately high affinity for 5-HT7, high affinity for 5-HT2, but only 24-51% activation of 5-HT2

3/4)  5-MeO-MIPT
      Very high affinity for 5-HT7, and moderately high affinity for 5-HT2. Martin Ball considers it to be the second best tool for non-duality work,            but some people claim that it's not that good, I don't know.

5)    DPT, 2C-E, 5-MeO-DIPT, DMT(?)

 

 You can read more about it here

 

 

Definitely, over 10 gr dried shrooms with lemon take. 

[bambi]

On 30/05/2024 at 11:04 PM, What Am I said:

LSD has a higher likelihood of producing unified states of consciousness via energetic release. That's not to say it's overall better though. There's plenty of drawbacks in comparison to mushrooms.

What are the drawbacks besides time?

LSD seems like a more holistic integrative healing tool to me. Even helps Dopaminergic system. I think it has better healing for those who have abused sitmulants

For me Mushrooms are more narrow, more unstable, more loopy, more scary tbh. LSD seems more balanced and stable and less loopy, more clear, while still being intense