Thoughts on auto immune disorders?

[PurpleTree]

Where do they come from?

Can they be tested for by doctors?

Solutions?

Are seemingly more people getting such auto immune disorders than decades ago?

 

[PurpleTree]

Autoimmune disease i meant but you get the gist.

[PurpleTree]

I think Leo has some autoimmune issues going on too. Would be nice if he made an episode on it. Although maybe it’s too depressing.

[Yimpa]

3 hours ago, PurpleTree said:

Autoimmune disease i meant but you get the gist.

Autoimmune disease and disorder mean the same thing.

[Leo Gura]

Lots of toxins and bad chemicals everywhere. The human organism is not made for such.

[RendHeaven]

2 hours ago, Michael569 said:

If you get diagnosed early on in life, it is most likely genetics only.

We can't rule out the possibility that environmental toxicity in the mother might transfer to the fetus

It's a messy world out there...

[PurpleTree]

4 hours ago, Michael569 said:

Its a huge topic with tons of good research and yet I don't think we fully know what is the exact cause of the loss of immune "self"-tolerance and initiation of self-attack. We've got plenty of good evidence pointing towards genetics, environmental toxins, major deficiencies, microbiome disruptions, diet, lifestyle, chronic inflammation, mis-diagnosis, untreated allergies, intolerances, gut permeability etc. 

If you get diagnosed early on in life, it is most likely genetics only. For people who get diagnosed late in life, there was probably a strong lifestyle factor involved but usually you're completely unaware until the first flareup

We know mechanistically what is happening for example in Coeliac and can pinpoint it to a cascade of molecules that trigger the self-attack but we don't yet know the "why" although we can see genetic susceptibility being a critical factor of excessive gliadin binding to the antigen-presenting immune cells. 

Other like MS or Lupus seem to be heavily linked to toxin exposure in early life as well as vitamin D deficiencies (among other things) but also heavily rely on genetic susceptibility

Each of those conditions has very unique aetiology, very specific mechanisms but there are also many similarities you can observe. 

They are really tough conditions for the people who experience them. The drugs used are strong and have lots of side effects and people often go through flare ups and remissions over and over. It can be pretty depressing, yeah.

Full remissions does sometime happen so in some people autoimmunity is very manageable (I'm trying to avoid the word "curable on purpose because there is a lifelong susceptibility in those who've had first attack) but it depends on many things. 

In my practice I've seen two  interesting cases of symptom remission, one with MS, the other with ankylosing spondylitis, both seemed to have been triggered by a combination of lifestyle & toxin exposure (both were smokers), both were stressed a lot and both had disrupted sleep pattern (and probably genetics) but both seemed to have got better with lifestyle optimisation and diet improvement + lots of supplements, some herbs. . Its been years now and both seem relatively stable the last time I checked (i like checking on old clients every now and then) so there are options available to people. 

Thanks. What are some of your favourite supplements for autoimmune disorders?

[Yimpa]

On 1/16/2025 at 7:05 AM, Michael569 said:

We'd also want to explore family health history where possible and where known and as far back as we can. 

Do you include mental health?