PurpleTree

Thoughts on auto immune disorders?

9 posts in this topic

Where do they come from?

Can they be tested for by doctors?

Solutions?

Are seemingly more people getting such auto immune disorders than decades ago?


 

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I think Leo has some autoimmune issues going on too. Would be nice if he made an episode on it. Although maybe it’s too depressing.

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3 hours ago, PurpleTree said:

Autoimmune disease i meant but you get the gist.

Autoimmune disease and disorder mean the same thing.


I AM autistic

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Its a huge topic with tons of good research and yet I don't think we fully know what is the exact cause of the loss of immune "self"-tolerance and initiation of self-attack. We've got plenty of good evidence pointing towards genetics, environmental toxins, major deficiencies, microbiome disruptions, diet, lifestyle, chronic inflammation, mis-diagnosis, untreated allergies, intolerances, gut permeability etc. 

If you get diagnosed early on in life, it is most likely genetics only. For people who get diagnosed late in life, there was probably a strong lifestyle factor involved but usually you're completely unaware until the first flareup

We know mechanistically what is happening for example in Coeliac and can pinpoint it to a cascade of molecules that trigger the self-attack but we don't yet know the "why" although we can see genetic susceptibility being a critical factor of excessive gliadin binding to the antigen-presenting immune cells. 

Other like MS or Lupus seem to be heavily linked to toxin exposure in early life as well as vitamin D deficiencies (among other things) but also heavily rely on genetic susceptibility

Each of those conditions has very unique aetiology, very specific mechanisms but there are also many similarities you can observe. 

They are really tough conditions for the people who experience them. The drugs used are strong and have lots of side effects and people often go through flare ups and remissions over and over. It can be pretty depressing, yeah.

Full remissions does sometime happen so in some people autoimmunity is very manageable (I'm trying to avoid the word "curable on purpose because there is a lifelong susceptibility in those who've had first attack) but it depends on many things. 

In my practice I've seen two  interesting cases of symptom remission, one with MS, the other with ankylosing spondylitis, both seemed to have been triggered by a combination of lifestyle & toxin exposure (both were smokers), both were stressed a lot and both had disrupted sleep pattern (and probably genetics) but both seemed to have got better with lifestyle optimisation and diet improvement + lots of supplements, some herbs. . Its been years now and both seem relatively stable the last time I checked (i like checking on old clients every now and then) so there are options available to people. 

Edited by Michael569

“If you find yourself acting to impress others, or avoiding action out of fear of what they might think, you have left the path.” ― Epictetus

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Lots of toxins and bad chemicals everywhere. The human organism is not made for such.


You are God. You are Truth. You are Love. You are Infinity.

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2 hours ago, Michael569 said:

If you get diagnosed early on in life, it is most likely genetics only.

We can't rule out the possibility that environmental toxicity in the mother might transfer to the fetus

It's a messy world out there...


It's Love.

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4 hours ago, Michael569 said:

Its a huge topic with tons of good research and yet I don't think we fully know what is the exact cause of the loss of immune "self"-tolerance and initiation of self-attack. We've got plenty of good evidence pointing towards genetics, environmental toxins, major deficiencies, microbiome disruptions, diet, lifestyle, chronic inflammation, mis-diagnosis, untreated allergies, intolerances, gut permeability etc. 

If you get diagnosed early on in life, it is most likely genetics only. For people who get diagnosed late in life, there was probably a strong lifestyle factor involved but usually you're completely unaware until the first flareup

We know mechanistically what is happening for example in Coeliac and can pinpoint it to a cascade of molecules that trigger the self-attack but we don't yet know the "why" although we can see genetic susceptibility being a critical factor of excessive gliadin binding to the antigen-presenting immune cells. 

Other like MS or Lupus seem to be heavily linked to toxin exposure in early life as well as vitamin D deficiencies (among other things) but also heavily rely on genetic susceptibility

Each of those conditions has very unique aetiology, very specific mechanisms but there are also many similarities you can observe. 

They are really tough conditions for the people who experience them. The drugs used are strong and have lots of side effects and people often go through flare ups and remissions over and over. It can be pretty depressing, yeah.

Full remissions does sometime happen so in some people autoimmunity is very manageable (I'm trying to avoid the word "curable on purpose because there is a lifelong susceptibility in those who've had first attack) but it depends on many things. 

In my practice I've seen two  interesting cases of symptom remission, one with MS, the other with ankylosing spondylitis, both seemed to have been triggered by a combination of lifestyle & toxin exposure (both were smokers), both were stressed a lot and both had disrupted sleep pattern (and probably genetics) but both seemed to have got better with lifestyle optimisation and diet improvement + lots of supplements, some herbs. . Its been years now and both seem relatively stable the last time I checked (i like checking on old clients every now and then) so there are options available to people. 

Thanks. What are some of your favourite supplements for autoimmune disorders?

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@RendHeaven true. Placenta does protect from a lot of things but certainly possible that epigenetic changes could happen in utero due to exposure of foreign substances leading to over or under-expression for different proteins coding for parts of the immune system like T-regs or CD4+ cells which are responsible for immune tolerance (among many other things). 

@PurpleTree couldn't tell you, depends from one person to another and depends on the particular diagnosed condition.

I'd see supplements as an extra 2% bonus on the top of major lifestyle/dietary protocols that need to happen first. On their own most supplements are quite weak in the absence of more holistic approach

With an autoimmune disease, for example, I'm immediately looking for existence of habits that need to be corrected (drinking, smoking, vaping, poor diet, late sleep times, physical passivity, lack of down time etc). 

I'm looking at the diet - antioxidant intake, sodium intake, nutritional deficiencies, fibre intake (in some fibre is contraindicated tho) excessive intake of foods associated with worsening of symptoms (of that particular disease with respect to existing evidence), polyphenol intake (at least those where we have some decent evidence of efficacy) etc. 

We're looking at environmental exposure - heavy metals, microplastics, water , air pollution, daily exposure to chemicals...we also try to explore environmental exposure across lifetime but that tends to be difficult to do becaue we rely heavily on individual recollection. 

We'd also want to explore family health history where possible and where known and as far back as we can. 

And as a cherry on the top of that, we might add a few supplements with existing data or where efficacy is speculative/experimental (I usually try to let the person know whether evidence exists and what quality is available). Some people are open to experimentation and some don't want to take risks so again, person to person differences 

 

Edited by Michael569

“If you find yourself acting to impress others, or avoiding action out of fear of what they might think, you have left the path.” ― Epictetus

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