Is it OK to Chellate HeavyMetals while having a LeakyGut ?

[BlurryBoi]

I worry the chellation process might not work and make things worse because of having intestinal Permeability problems (like IrritableBowelSyndrome etc) wich might be a different paradigm than a healthy hermetic digestive system...

 

In this situation, should we postpone the chellation for after having healed the permeability ? (might be paradoxal if heavymetals are causing it) 

Or is it ok to do it but with specific supplementation ? (like covering the wounds temporarily)

Or is it just fine anyways ?

 

Thanks for the help ! 🙏🏻

 

[Michael569]

It's a complex topic with tons of nuances. 

Intestinal permeability is quite difficult to measure and diagnose not to mention it's not even fully understood in relation to disease.

The problem is that tight junctions between the epithelial cells loosen and tighten up all the time in response to various stimuli. For example eating bunch of gluten will stimulate tight junctions to open up because gliadin peptides which are indigestible due to proline content seem to have that effect for some reason. They may also react to minor infections and possibly even to periods of high stress, sleep deprivation etc. 

It also has some role in immune surveillance to allow things like antigen presenting cells to pass in and out.

And finally there is potential for genetic variables that in some people the spaces between epithelial junctions might be naturally wider. 

I believe there is no gold standard tests but polyethylene glycol in combination with something like Zonulin test might be relevant. But again, there is high risk of false positive. 

So as a first line of approach you want to be sure that's what's going on. A presence of something like IBS doesn't necessarily mean you also have increased permeability. But you could consider something like PEG test for a start.

With regards to chelation, it might be a good idea to sort out the gut health before anything else, yeah.

Since your gut is a major elimination channel alongside liver and kidneys so you wanna "prepare the ground" properly before embarking on detox, this is my major criticism of how chelation is approached around here - jump on supplement wagon without any preparation or understanding what it is that's actually about to happen. 

So regardless of what you do, best spend some time preparing your body for, fix what needs to be fixed first. The last thing you want happen is bunch toxin-bound carriers packaged in liver becoming reopened and recirculated around the body because the elimination wasn't ready to take the hit. This does happen in case of beta-glucuronidase overgrowth for example.

 

Edited January 5 by Michael569