I've noticed a few posts on the DMT subreddit where people are loading carts with straight DMT freebase in crystal form and then heating the cart with something like a hairdryer to melt the DMT into liquid form. At this point, they claim to be able to vape it with the same ease as a PG/DMT mix, with the obvious difference that it's now much stronger and you can avoid ingesting the unwanted chemical of PG.
Anyone ever try something similar with 5-MeO-DMT? The main difference I see is in the two molecules' melting points. DMT freebase melts at ~104F and 5-MeO-DMT freebase melts at ~151F. It's hard to say without doing some testing, but the higher melting point may be an issue in performing this method. At least for DMT freebase, it stays melted for 30-60 minutes after heating and then recrystalizes in the cart.
https://www.reddit.com/r/DMT/comments/1bgkcn9/dmt_vape_no_pgvg/
https://www.reddit.com/r/DMT/comments/n1mwf3/no_pg_required_just_heat_the_cart_until_its_all/