I used to do drugs when I was out of home for 1,5 years (at university).
Mainly I wanted it for spiritual reasons, but well, most of the time it was for curiosity, fun or emotional comfort. I came back home started on a different university from the beginning, now living with parents. I used to be angry that I have no opportunity to take anything, because I wasn't left alone for longer than 12 hours.
However, after some time, I came to realization that I don't need it in any way. It can't be possible that enlightenment (or as I like to call it ascension which has a stronger meaning) is dependent on outer world. I mean not completely independent, but it's impossible that it requires serotonin/dopamine/NDMA altering, which is actually quite too complex in terms of doing it manually by a human. Yeah and I felt that I'm irritating serotonin terminals and don't accept how my brain works sober (which is actually against self-acceptance policy).