mattslev

As far as I can tell, the belief that some ayahuasca brews contain 5-MeO-DMT derives from a single several-decades-old report that appears to have been mistaken. The admixture plant being referenced for such claims is Diplopterys cabrerana, aka chaliponga, which is used in some indigenous lineages in place of the far more commonly used plant Psychotria viridis, or chacruna, as the source of N,n-DMT to be combined with the ayahuasca vine and its MAOIs. All recent analyses of Diplopterys cabrerana that I've found have failed to find any 5-MeO-DMT whatsoever, not even trace amounts, in that plant. This includes samples provided by individuals who were absolutely convinced their material was rich in 5-MeO-DMT. What testing has revealed about Diplopterys cabrerana is that it is loaded with N,n-DMT, with far higher concentrations than Psychotria viridis.

Beautiful account of your journey

Beat me to it. I can't think of anyone alive whose view of psychedelics I care less about than Jordan Peterson.

Does anyone know the instrumental piece @Leo Gura used for his "Gallery of Absolute Infinity" at the end of this video? Reminds me a bit of this song:

Iboga is seriously powerful medicine. Consult with someone who is highly experienced serving it and can conduct a proper medical and psychological screening.

From a safety perspective, you should be fine to do ayahuasca an hour after bufo/5-MeO, which will have been thoroughly metabolized. Whether having both experiences in one day is too much psychologically is entirely dependent on you. Trust your instinct. Ingesting bufo/5-MeO after ayahuasca is where you need to exercise extreme caution due to the presence of MAOIs in the Banisteriopsis caapi vine, as that in combination with 5-MeO, which is a strong serotonin re-uptake inhibitor, can lead to serotonin syndrome. Potentially fatal. At a minimum, it is advised not to take 5-MeO for at least 24 hours after ayahuasca. Kambo is another medicine that can be lethal in combination with 5-MeO. Article with great information about the pharmacology involved: https://www.spiritpharmacist.com/blog/2020/6/13/a-tale-of-two-tryptamines-nn-dmt-and-5-meo-dmt-in-combination-with-maois

Yopo, which is made from Anadenanthera peregrina seeds—much like snuff made from Anadenanthera colubrina that is called vilca or cebil—contains only trace amounts of 5-MeO-DMT and N,n-DMT. The primary psychoactive compound in those snuffs is bufotenine, which is also an extremely powerful tryptamine. The snuffs that contain high concentrations of 5-MeO are made from the resin of several Virola tree species and are called epena, nyakwana, parica, etc by various tribes.

I would think that keeping Sonoran Desert toads in captivity does affect the nature of their secretions, at least over time. These animals spend approximately 10 months out of the year underground in total darkness. Such conditions likely explain why they produce such high concentrations of 5-MeO-DMT, which can be up to 30 percent of the secretion by weight. Prolonged exposure to complete darkness, ie total deprivation of light, results in a a flood of melatonin, which is a precursor to 5-MeO. A similar process can happen in humans who go on darkness retreats, where they report experiences that are identical to N,n-DMT and 5-MeO-DMT. After several days of being deprived of any light, they begin producing more melatonin that seems to then be converted to DMT first followed soon after by 5-MeO. So my guess is that keeping these toads in captivity eventually causes them to produce less 5-MeO--and perhaps to even stop entirely over time--as conditions of extensive darkness are not being replicated, disrupting their natural life cycle.