forestfog

Church of the Sacred Synthesis March 7 Press Release The Church of the Sacred Synthesis (The Church) is pleased to announce that it has confirmed the presence of Psilomethoxin (4-HO-5-MeO-DMT) in its mushroom fruiting bodies. These findings have been independently confirmed using triple quadrupole LC/MS instrumentation at the Chemical Purification, Analysis, and Screening Facility supervised by its director at the University of South Florida (USF) on Tuesday March 5, 2024. The Church made the Psilomethoxin reference standard that it promised and will be able to test submitted sacramental Psilomethoxin contained in fruiting bodies provided by others who grow the sacrament on their own. The Church has a distribution partner who will be making Psilomethoxin available over the counter (OTC) in a GMP formulation. We have a biotech partner who will be making Psilomethoxin OTC in a GMP formulation from yeast using gene editing. We have a university partner who will be conducting clinical trials on Psilomethoxin on the way towards an FDA indication. The Church has sued Usona and others for defamation in Texas state court in Austin. The basis for our suit is that Usona is liable for their test of the anonymous unauthenticated sacrament due to the reckless disregard for the truth (actual malice) in the failure of their methodology to extract Psilomethoxin using methanol rather than water which Psilomethoxin is soluble in. Any questions or press inquiries are best directed to press@psilomethoxin.com https://thesacredsynthesis.com/church-of-the-sacred-synthesis-march-7-press-release/

@Girzo The founders of the church have been aware of this article and have shared it on social media months ago. In the interview below (56:20), Hammilton Morris said that he didn't found psilomethoxin on his first analysis on his sample, but this could be due to measuring issues as "these things can be difficult to detect especially without an analytic reference". He also said that producing psilomethoxin in a lab is very difficult and would take months to eventually make a small amount of it.

@Girzo Sorry, but I don't think your description of Martins position makes justice to his long essay. If one would want to summarise his position, these could be the quotes from the essay: "From my direct experience of bio-assaying the sacrament of CP, my answer is yes, these mushrooms are clearly different than regular psilocybin mushrooms. I am not able to prove it in any way, for as I stated, I’m not a chemist or a mycologist and cannot, with any authority, speak on such issues. From my experience, the mushrooms provided to me by CP are noticeably different in just about every way from any prior species of psilocybin mushrooms I’ve ingested ... All I can say with certainty is that in my personal experience, the mushrooms provided by CP have felt distinctly different from any other mushrooms I’ve experienced previously. Does that prove that they have psilomethoxin in them? No. Is it possible that it’s just the placebo effect? Yes. Do I think so? No." Regarding the accusations of being a scam, Martin writes: "This is a question that some people have asked me about this situation. Here I’m going to definitively side with CP in that in my interactions with them, and especially getting to experience first-hand the community that is building up around CP via my participation and observations at the EntheoGenesis event, my assessment is that they are unquestioningly sincere, well-meaning, big-hearted, and genuine with all that they are doing. I do not believe that anyone involved with CP is looking to deceive or scam anyone and that they are very sincere in their beliefs about what they are providing and what they are doing. While this doesn’t address the psilomethoxin question directly, it does address their veracity as a religious and non-proft organisation that is focused on helping vets and getting them access to psychedelic therapy via their sacrament, regardless of what it chemically contains. They sincerely believe that their sacrament is what they say it is, and hope to have the scientific evidence to support this claim at some point in the future. I do not believe (my subjective opinion) that anyone involved with CP is intentionally misleading anyone for personal gain or profit. I’ve seen no evidence that they are cynically distributing a product that they know to be something other than what they are claiming it to be."

I have done dosages between 250 mg - 1.2 g in form of capsules, chocolate and gummies. Compared to Martins experiment on the video where he also took aprox. 1.2 g, I was expecting a stronger effect and for now don't find appealing to eventually be in a "boundless state" for longer than vaporised 5-MeO-DMT can provide. Overall under the effect, I feel functional without visual enhancements, emotional waves, active imagination etc. On lower dosages I feel serenity, distance from the narrative mind and in general in a more contemplative mind space. On higher doses the initial stages of boundary dissolution (or like the end tail of a 5-MeO session) but still with a clear mind. I haven't yet stacked it with other molecules, but I have heard reports that when done with classic mushrooms or LSD, the specialness of the sacrament comes clear as it is said to give the experience a whole different kind of depth. Personally this makes sense intuitively. I understand the appeal to "faith" more as a legal term made in the context of religious freedom.

I have experimented with the churchs mushroom and can confirm it has a - albeit subtle - 5-MeO-DMT energy to it and doesn't build up tolerance. Different from psilocybin or DPT. The article claims they only found psilocybin, psilocin and baeocystin in *their* sample suggesting people like me are having a placebo...:) The effect is gentle and can't be compared to 5-MeO in potency, but it does seem to pleasantly lower the minds reactivity serving thus as a good introductory for a full release 5-MeO-DMT session.

With the direct Emesh vaporizer you burn the remaining residues as a routine, although normally after optimal vaping of pure 5-MeO freebase there hardly are any residues on the mesh. I can't think of anything more convenient. Demonstrated on the video at 4:36.

After using the manual Eclipse vape for years, few months ago I got into the Emesh vaping technique and imo it's definitely worth the investment. Very cost effective, I would estimate one needs a third of the normal dose and even the experience feels smoother, similar to snorting/plugging. But if you use the oil pipe, a normal lighter works well for freebase 5-MeO, no need for a torch.

Meanwhile Mindset Pharma is hopeful that their molecule will be therapeutically (maybe metaphysically also?) better than 5-MeO-DMT. "Mindset Pharma Announces Further Preclinical Results Demonstrating Strong Efficacy and Improved Safety Profile for its 5-MeO-DMT-Inspired Drug Candidate, MSP-4018 TORONTO, Sept. 20, 2021 (GLOBE NEWSWIRE) -- Mindset Pharma Inc. (CSE: MSET) (FSE: 9DF) (OTCQB: MSSTF) ("Mindset" or the "Company"), a drug discovery and development company focused on creating optimized and patentable next-generation psychedelic medicines to treat neurological and psychiatric disorders with unmet medical needs, today announced that preclinical proof-of-concept data comparing its clinical candidate, MSP-4018, against 5-MeO-DMT further demonstrated strong efficacy and an improved safety profile as a next generation psychedelic medicine. “Given the strong preclinical efficacy and safety data in support of MSP-4018, combined with our expedited manufacturing process, we believe our Family 4 clinical candidate has the potential to provide a safer and more scalable therapeutic alternative to first-generation 5-MeO-DMT. We believe this preclinical data will enable us to quickly advance this novel compound into human clinical trials,” said James Lanthier, CEO of Mindset. “The latest preclinical proof-of-concept data showed that, in addition to its strong efficacy, both locomotor activity and rearing behavior for MSP-4018 did not decline at a range of doses tested, compared to the profound decline observed in 5-MeO-DMT, indicating a remarkably improved safety profile for MSP-4018. In addition, we saw further evidence of psychedelic activity, reflected in the head twitch response of mice,” concluded Joseph Araujo, Chief Scientific Officer of Mindset. Mindset’s Family 4 compounds are DMT and 5-MeO-DMT-inspired novel drug candidates that offer a broad range of pharmacological diversity suitable for in-clinic settings. The Company has run a battery of specialized in-vitro and in-vivo tests on its patent-pending novel compounds to select the optimal psychedelic drug candidates for progressing towards human clinical trials. To watch a video of Mindset’s CEO discussing the announcement in greater detail, please visit: https://youtu.be/JeyBUp2klXk."

Recently Bernardo Kastrup wrote about the lack of understanding by Sam Harris of consciousness as fundamental (ontological idealism). "Indeed, idealism is one of the foundational topics in both Eastern and Western philosophy. A basic understanding of idealist claims—the claims of Berkeley, Swedenborg, Kant, Hegel, Schopenhauer, and arguably even Plato, Parmenides and Empedocles—is part of the 'ABC' of philosophy. That someone who "received a degree in philosophy from Stanford University and a Ph.D. in neuroscience from UCLA" (quote from Harris's website) can fail so resoundingly at such a foundational level is, well, quite amazing. Harris conflates very basic concepts. For instance, he conflates personal consciousness with consciousness as ontic category, something no self-respecting philosophy freshman would do (it's like conflating a wooden table with wood). Parts of his 'argument against idealism' also imply a direct conflation of idealism with solipsism, two entirely different metaphysics that, again, no self-respecting freshman in philosophy would conflate. How is that possible?" https://www.bernardokastrup.com/2021/06/is-ad-hominem-always-fallacy.html

I agree with your point in general, but I wonder makes you describe Martin as "just some hippie dude" doing "shamanic work"? Is this some rhetorical expression or you genuinely think these are accurate definitions? Martin has deconstructed the shamanic paradigm in the psychedelic scene and many people dislike him because of this. Also hard to see Martin as a hippie. In your interview with him, you seemed to respect his experience and views about 5-MeO. That video seems to be one of the most watched videos on YT. For now the testimonials that have come out from Martins clients have praised his work and how he was very attentive in the session between hits if they didn't want to go further with the experience. He certainly did things that might seem weird, but he explains that taking 5-MeO along with the client was for him enter the same energetic space with the client to perceive more accurately the energetic blockages etc. Do you find this inconceivable?

@High-valance clear explanation. As I perceive it, Martin Ball, @Leo Gura, Rupert Spira and Bernardo Kastrup are all contemporaries that basically agree on the fundamentals, but communicate it a bit differently.

For contextualisation, it seems that the OPs comment is a response to some Rupert Spiras youtube talk. It seems that Rupert Spiras nonduality version and its "direct path" method has lot in common with ideas advocated on this forum about the nature of consciousness.

@machii From your OP description there is a good probability that I have been getting my 5-MeO from the same source. Before their current HCL and freebase options, they used to have it in oxalate salt form. Personally never tested it, but from their different batches (slight colour differences) and salt forms I have always got a solid 5-MeO experience, and the toad venom that I got some years ago before the synth was available feels nowadays pretty obsolete...even a bit disgusting to be honest. Go slowly and do not underestimated the power of it when administrated optimally.

@Gneh Onebar Very true on how to describe the experiences they necessarily will have a dualistic sense. I have listened to Baches interviews and just recently bought the book which I'm looking forward to read even more after your opinion of it. It certainly seems to be a landmark in psychonautics. Not that the book would give me the answers, but personally I'm especially interested if such high doses of LSD experiences have the same inner consistency cross individuals that 5-MeO seems to deliver. Then I'm curious to read more on why Bache thinks that he could have "gone slower" on his explorations and on his difficulties in integrating his experiences to his ordinary life.

In this James Jesso's interview Bache responds to the question about 5-MeO-DMT starting at 32:15. From it I personally get the sense that Bache is not very familiar with 5-MeO-DMT specially with the more long lasting effects of other ROAs than vaping. Even though his perspective on how there is infinite layers of ultimacy and one should be cautious on drawing conclusions from single experiences is a valid one, I can't avoid to speculate that his observations have still an dualistic element to them that possibly would not exist if he would have explored consciousness with 5-MeO-DMT. But this is merely based on his descriptions as I personally have not done such high doses of LSD.